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KMID : 0903519800230020123
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1980 Volume.23 No. 2 p.123 ~ p.130
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Studies on the Relationship of the Preparation of Thiamine Derivatives
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Abstract
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Thiamine derivatives of thiamine tetrahydrofurfuryl disulfide (TTFD) and thiamine propyl disulfide (TPD) were obtained in a good yield and purity by use of thiothiamine (SB₁) and also described in details for the preparing sodium tetralrydrofurfuryl thiosulphate (Bunte´s salt)with and without KI. The optimum reaction conditions for the preparation of TTFD was set in which the Box-Wilson plan was applied. The reaction conditions are as follows;
1. pH value of aqueous solution of thiol type of B₁·HCl;12.09
2. Quantity of Bunte´s salt (to B₁·HCl 20G); 35.01g
3. Reaction temperature; 15.59℃
Studies on ultraviolet absorption were made at various pH and showed that the absorption maxima are shifted with change of pH. The absorption maxima are at 244∼246㎚, 234∼235㎚ in TTFD, and 245∼246㎚, 233∼235㎚ in TPD. The structure was proved by the infrared spectral evidence. Quantitative determination vans studied.
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